HCID 22347452, compound → HCID 9800616, compound

HRID 897022Notes

Reaction equation

HRID 897022 reaction equation
C(OC([NH:11][C:12]1[CH:13]=[C:14]([S:25]([NH2:28])(=[O:27])=[O:26])[CH:15]=[CH:16][C:17]=1[C:18]([O:20]C(C)(C)C)=[O:19])=O)C1C=CC=CC=1.C([O:36][C:37](=O)[C:38]1[C:39](=[CH:50][C:51]([O:54][CH3:55])=[CH:52][CH:53]=1)[NH:40][C:41](OC1C=CC=CC=1)=[O:42])C1C=CC=CC=1>>[CH3:55][O:54][C:51]1[CH:50]=[C:39]2[C:38]([C:37](=[O:36])[N:28]([S:25]([C:14]3[CH:13]=[C:12]([NH2:11])[C:17](=[CH:16][CH:15]=3)[C:18]([OH:20])=[O:19])(=[O:26])=[O:27])[C:41](=[O:42])[NH:40]2)=[CH:53][CH:52]=1

Participants

3

Reactant 2

HCID 22347452HCID 22347452, compoundHCID 22347462HCID 22347462, compound

Product 1

HCID 9800616HCID 9800616, compoundYield 3.1%

Procedure

From 500 mg (1.23 mmol) of 3-benzyloxycarbonylamino-4-t-butoxycarbonylbenzenesulfonamide and 460 mg (1.22 mmol) of 4-methoxy-2-N-phenoxycarbonylanthranilic acid benzylester in a similar manner to Preparation Example 17, 15 mg (yield 3.1%: 4 steps) of the title compound was obtained. Property: colorless crystals, melting point: >200° C. (decomposition), PMR (δppm, DMSO-d6): 3.82 (3H, s), 6.58 (1H, s), 6.80 (1H, d), 7.16 (1H, d), 7.56 (1H, s), 7.80 (1H, d), 7.90 (1H, d), 11.49 (1H, s).

Sources & evidence

ORD record
ord-a1a39fcca1734e708e52a984bf74dbfd
Source dataset
uspto-grants-2005_07
Patent number
US06921766B1

Reaction notes

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