HCID 22347456, compound → HCID 9821064, compound

HRID 897023Notes

Reaction equation

HRID 897023 reaction equation
C(OC([NH:11][C:12]1[CH:13]=[C:14]([S:25]([NH2:28])(=[O:27])=[O:26])[CH:15]=[CH:16][C:17]=1[C:18]([O:20]C(C)(C)C)=[O:19])=O)C1C=CC=CC=1.C([O:36][C:37](=O)[C:38]1[C:39](=[CH:50][C:51]([OH:54])=[CH:52][CH:53]=1)[NH:40][C:41](OC1C=CC=CC=1)=[O:42])C1C=CC=CC=1>>[OH:54][C:51]1[CH:50]=[C:39]2[C:38]([C:37](=[O:36])[N:28]([S:25]([C:14]3[CH:13]=[C:12]([NH2:11])[C:17](=[CH:16][CH:15]=3)[C:18]([OH:20])=[O:19])(=[O:26])=[O:27])[C:41](=[O:42])[NH:40]2)=[CH:53][CH:52]=1

Participants

3

Reactant 2

HCID 22347456HCID 22347456, compoundHCID 22347462HCID 22347462, compound

Product 1

HCID 9821064HCID 9821064, compoundYield 4%

Procedure

From 620 mg (1.53 mmol) of 3-benzyloxycarbonylamino-4-t-butoxycarbonylbenzenesulfonamide and 550 mg (1.51 mmol) of 4-hydroxy-2-N-phenoxycarbonylanthranilic acid benzylester in a similar manner to Preparation Example 17, 25 mg (yield 4%: 4 steps) of the title compound was obtained. Property: colorless crystals, melting point: >200° C. (decomposition), PMR (δppm, DMSO-d6): 6.48 (1H, s), 6.61 (1H, d), 7.14 (1H, d), 7.51 (1H, s), 7.70 (1H, d), 7.90 (1H, d), 10.80 (1H, s), 11.39 (1H, s).

Sources & evidence

ORD record
ord-ab51402b867b4ad2b83800613bc5e807
Source dataset
uspto-grants-2005_07
Patent number
US06921766B1

Reaction notes

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