HCID 22347436, compound → HCID 9930602, compound

HRID 897024Notes

Reaction equation

HRID 897024 reaction equation
C(OC([NH:11][C:12]1[CH:13]=[C:14]([S:25]([NH2:28])(=[O:27])=[O:26])[CH:15]=[CH:16][C:17]=1[C:18]([O:20]C(C)(C)C)=[O:19])=O)C1C=CC=CC=1.C([O:36][C:37](=O)[C:38]1[C:39](=[CH:50][CH:51]=[C:52]([Cl:54])[CH:53]=1)[NH:40][C:41](OC1C=CC=CC=1)=[O:42])C1C=CC=CC=1>>[Cl:54][C:52]1[CH:53]=[C:38]2[C:39](=[CH:50][CH:51]=1)[NH:40][C:41](=[O:42])[N:28]([S:25]([C:14]1[CH:13]=[C:12]([NH2:11])[C:17](=[CH:16][CH:15]=1)[C:18]([OH:20])=[O:19])(=[O:26])=[O:27])[C:37]2=[O:36]

Participants

3

Reactant 2

HCID 22347436HCID 22347436, compoundHCID 22347462HCID 22347462, compound

Product 1

HCID 9930602HCID 9930602, compoundYield 26%

Procedure

From 300 mg (0.74 mmol) of 3-benzyloxycarbonylamino-4-t-butoxycarbonylbenzenesulfonamide and 310 mg (0.81 mmol) of 5-chloro-2-N-phenoxycarbonylanthranilic acid benzylester in a similar manner to Preparation Example 17, 75 mg (yield 26%: 4 steps) of the title compound was obtained. Property: colorless crystals, melting point: >200° C. (decomposition), PMR (δppm, DMSO-d6): 7.13-7.20 (2H, m), 7.56 (1H, s), 7.72 (1H, d), 7.82 (1H, s), 7.90 (1H, d), 11.68 (1H, s).

Sources & evidence

ORD record
ord-7c7dd4c284fd4a7d85d434c26ee643f4
Source dataset
uspto-grants-2005_07
Patent number
US06921766B1

Reaction notes

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