反应详情

26.00 g (102.0 mmol) of 2-bromo-1-(3-methylbut-2-enylthio)benzene, 180 ml of toluene and 23.20 g (122.0 mmol) of para-toluenesulphonic acid are introduced into a three-necked flask. The reaction medium is refluxed for four hours and is then evaporated to dryness. The residue is taken up in aqueous sodium hydrogen carbonate solution and extracted with ethyl acetate, and the organic phase is separated out after settling, dried over magnesium sulphate and evaporated. The residue obtained is purified by chromatography on a column of silica and eluted with heptane. 20 g (76%) of the expected compound are collected in the form of an orange-coloured oil.

1. temperatureThe reaction medium is refluxed for four hours
2. customis then evaporated to dryness
3. extractionextracted with ethyl acetate
4. customthe organic phase is separated out
5. dry with materialdried over magnesium sulphate
6. customevaporated
7. customThe residue obtained
8. customis purified by chromatography on a column of silica
9. washeluted with heptane
10. custom20 g (76%) of the expected compound are collected in the form of an orange-coloured oil