Cyclohexyl isocyanate → HCID 60018594, compound

HRID 897078Notes

Reaction equation

[CH:1]1([N:7]=[C:8]=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:10][CH2:11][C:12]1[N:20]=[C:19]2[C:15]([N:16]=[CH:17][N:18]2[C@@H:21]2[O:25][C@H:24]([C:26]([NH:28][CH2:29][CH3:30])=[O:27])[C@@H:23]([OH:31])[C@H:22]2[OH:32])=[C:14]([NH:33][CH2:34][CH:35]([C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)[C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[N:13]=1>>[CH:1]1([NH:7][C:8]([NH:10][CH2:11][C:12]2[N:20]=[C:19]3[C:15]([N:16]=[CH:17][N:18]3[C@@H:21]3[O:25][C@H:24]([C:26]([NH:28][CH2:29][CH3:30])=[O:27])[C@@H:23]([OH:31])[C@H:22]3[OH:32])=[C:14]([NH:33][CH2:34][CH:35]([C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)[C:42]3[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=3)[N:13]=2)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

Reactant 2

HCID 18502Cyclohexyl isocyanate

HCID 59909598(2S,3S,4R,5R)-5-{2-(aminomethyl)-6-[(2,2-diphenylethyl)amino]-9H-purin-9-yl}-N-ethyl-3,4-dihydroxytetrahydro-2-furancarboxamide

Product 1

HCID 60018594HCID 60018594, compound

Procedure

The compound was prepared from cyclohexylisocyanate and (2S,3S,4R,5R)-5-{2-(aminomethyl)-6-[(2,2-diphenylethyl)amino]-9H-purin-9-yl}-N-ethyl-3,4-dihydroxytetrahydro-2-furancarboxamide (Preparation 11) according to the procedure used in Example 6.

Sources & evidence

ORD record: ord-13838ad29e8a45d58c3b39d4415d8b77
Source dataset: uspto-grants-2005_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06921753B2

Reaction notes

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