Benzenesulfonyl chloride → HCID 10284067, compound

HRID 897080Notes

Reaction equation

[C:1]1([CH:7]([C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)[CH2:8][NH:9][C:10]2[N:18]=[C:17]([CH2:19][NH:20][C:21]([NH:23][CH2:24][CH2:25][NH:26][CH:27]([CH3:29])[CH3:28])=[O:22])[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][N:14]3[C@@H:30]2[O:34][C@H:33]([C:35]([NH:37][CH2:38][CH3:39])=[O:36])[C@@H:32]([OH:40])[C@H:31]2[OH:41])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:48]1([S:54](Cl)(=[O:56])=[O:55])[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=1>>[C:1]1([CH:7]([C:42]2[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=2)[CH2:8][NH:9][C:10]2[N:18]=[C:17]([CH2:19][NH:20][C:21]([NH:23][CH2:24][CH2:25][N:26]([CH:27]([CH3:29])[CH3:28])[S:54]([C:48]3[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=3)(=[O:56])=[O:55])=[O:22])[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][N:14]3[C@@H:30]2[O:34][C@H:33]([C:35]([NH:37][CH2:38][CH3:39])=[O:36])[C@@H:32]([OH:40])[C@H:31]2[OH:41])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 7369Benzenesulfonyl chloride

HCID 58904386HCID 58904386, compound

Product 1

HCID 10284067HCID 10284067, compound

Procedure

The title compound was prepared from (2S,3S,4R,5R)-5-(6-[(2,2-diphenylethyl)amino]-2-{[({[2-(isopropylamino)ethyl]amino}carbonyl)amino]methyl}-9H-purin-9-yl)-N-ethyl-3,4-dihydroxytetrahydro-2-furancarboxamide (80 mg, 0.12 mmol) (Preparation 12) and benzenesulphonyl chloride (0.0017 ml, 0.14 mmol) by a similar method to that of Example 8.

Sources & evidence

ORD record: ord-05486d681a334cd2b1d0eb581eb0c9ce
Source dataset: uspto-grants-2005_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06921753B2

Reaction notes

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