N-[2-(diisopropylamino)ethyl]-1H-imidazole-1-carboxamide → n-({6-{[2,2-Bis(3-methylphenyl)ethyl]amino}-9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-9h-purin-2-yl}methyl)-n'-[2-(diisopropylamino)ethyl]urea

Participants

Role	Name	HCID	Charge
Reactant	N-[2-(diisopropylamino)ethyl]-1H-imidazole-1-carboxamide	HCID 21978296	—
Reactant	(2R,3R,4S,5R)-2-(2-(Aminomethyl)-6-{[2,2-bis(3-methylphenyl)ethyl]amino}-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydro-3,4-furandiol	HCID 60018578	—
Product	n-({6-{[2,2-Bis(3-methylphenyl)ethyl]amino}-9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-9h-purin-2-yl}methyl)-n'-[2-(diisopropylamino)ethyl]urea	HCID 10146508	—

Reaction Steps

The title compound was prepared from (2R,3R,45,5R)-2-(2-(aminomethyl)-6-{[2,2-bis(3-methylphenyl)ethyl]amino}-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydro-3,4-furandiol (Preparation 65) and N-[2-(diisopropylamino)ethyl]-1H-imidazole-1-carboxamide (Preparation 27) using a similar procedure to that used in Example 36.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06921753B2
Source dataset	uspto-grants-2005_07
ORD ID	ord-1f9cd6aea5224c2eb94466a2e4133381
Source note	uspto-grants-2005_07