HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2-Bis(4-methylphenyl)ethanamine → (2R,3R,4R,5R)-4-(Acetyloxy)-2-[(acetyloxy)methyl]-5-(6-{[2,2-bis(4-methylphenyl)ethyl]amino}-2-cyano-9H-purin-9-yl)tetrahydro-3-furanyl acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2-Bis(4-methylphenyl)ethanamine | HCID 13110446 | — |
| Reactant | (2R,3R,4R,5R)-4-(Acetyloxy)-2-[(acetyloxy)methyl]-5-(6-chloro-2-cyano-9H-purin-9-yl)tetrahydro-3-furanyl acetate | HCID 22948625 | — |
| Product | (2R,3R,4R,5R)-4-(Acetyloxy)-2-[(acetyloxy)methyl]-5-(6-{[2,2-bis(4-methylphenyl)ethyl]amino}-2-cyano-9H-purin-9-yl)tetrahydro-3-furanyl acetate | HCID 60018597 | — |
Reaction Steps
The compound was prepared from (2R,3R,4R,5R)-4-(acetyloxy)-2-[(acetyloxy)methyl]-5-(6-chloro-2-cyano-9H-purin-9-yl)tetrahydro-3-furanyl acetate (Preparation 45) and 2,2-bis(4-methylphenyl)ethanamine (J. Med. Chem., 1969, 12 (1), 9) using a similar method to that of Preparation 64.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06921753B2 |
| Source dataset | uspto-grants-2005_07 |
| ORD ID | ord-c88edb74982c406c9325528b02b46ff8 |
| Source note | uspto-grants-2005_07 |