HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Cyanide → 3-Chloro-5-(trifluoromethyl)pyridine-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine | HCID 1268075 | — |
| Catalyst | Tetrabutylammonium Bromide | HCID 74236 | — |
| Product | 3-Chloro-5-(trifluoromethyl)pyridine-2-carbonitrile | HCID 1473374 | 82.1% |
Reaction Steps
Solid sodium cyanide (0.29 g) was added to a stirred mixture of 3-chloro-2-fluoro-5-trifluoromethylpyridine (0.8 g) and tetrabutylammonium bromide (0.06 g) at 20-25° C., and stirred for 23 hours to give 3-chloro-2-cyano-5-trifluoromethylpyridine (0.68 g, 82% yield by hplc).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06921828B2 |
| Source dataset | uspto-grants-2005_07 |
| ORD ID | ord-a2b6be94861e467ea99473efde87ab04 |
| Source note | uspto-grants-2005_07 |