HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 897164Generated: October 30, 2026
2,3-Dichloro-5-(trifluoromethyl)pyridine → 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine
https://huagongshe.com/reaction/897164
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2,3-Dichloro-5-(trifluoromethyl)pyridine | HCID 112234 | — |
| Reactant | Potassium Fluoride | HCID 522689 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine | HCID 1268075 | 92.7% |
Reaction Steps
2,3-Dichloro-5-trifluoromethylpyridine (800 g) was added to a stirred mixture of anhydrous potassium fluoride (320 g) and anhydrous dimethylsulphoxide at 110° C. then heated at 120° C. for 2 hours and fractionally distilled under reduced pressure to give 3-chloro-2-fluoro-5-trifluoromethylpyridine (685 g) in a yield of 92% (98% purity).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06921828B2 |
|---|
| Source dataset | uspto-grants-2005_07 |
|---|
| ORD ID | ord-8d35ee869f354007a53ea8780377c22c |
|---|
| Source note | uspto-grants-2005_07 |
|---|
