反应详情

Into a 500 ml three-necked round-bottomed flask equipped with a stirrer, (S)-2,3-epoxy-2-trifluoromethylpropionic acid benzyl ester (20.9 g, 84.9 mmol, 99 ee %) was charged, and 180 ml of methanol was added for dissolution. Platinum oxide (1.63 g) was added, and then, the reaction system was substituted by hydrogen. After stirring at room temperature for 4 hours, platinum oxide was filtered off. The solvent was distilled off under reduced pressure, whereupon (S)-2,3-epoxy-2-trifluoromethylpropionic acid (11.9 g) was obtained (yield: 90%).

1. customInto a 500 ml three-necked round-bottomed flask equipped with a stirrer
2. filtrationplatinum oxide was filtered off
3. distillationThe solvent was distilled off under reduced pressure, whereupon (S)-2,3-epoxy-2-trifluoromethylpropionic acid (11.9 g)
4. customwas obtained (yield: 90%)