3-(Trifluoromethoxy)benzaldehyde → HCID 10253085, compound

HRID 897200Notes

Reaction equation

HRID 897200 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[O:9][C:8](=[O:13])[CH:7]=[C:6]2[NH:14][CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1.[F:21][C:22]([F:33])([F:32])[O:23][C:24]1[CH:25]=[C:26]([CH:29]=[CH:30][CH:31]=1)[CH:27]=O>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[O:9][C:8](=[O:13])[CH:7]=[C:6]2[NH:14][CH:15]1[CH2:20][CH2:19][N:18]([CH2:27][C:26]2[CH:29]=[CH:30][CH:31]=[C:24]([O:23][C:22]([F:21])([F:32])[F:33])[CH:25]=2)[CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 6051393-(Trifluoromethoxy)benzaldehydeHCID 22348060HCID 22348060, compound

Product 1

HCID 10253085HCID 10253085, compound

Procedure

According to Procedure A above, 6-methoxy-4-(piperidin-4-ylamino)-chromen-2-one and 3trifluoromethoxybenzaldehyde were allowed to react to give the title compound. MS (DCI/NH3) m/z 449 [M+H]+; 1H NMR (500 MHz, DMSO) δ ppm 7.66 (m, 2H), 7.59 (m, 2H), 7.51 (m, 1H), 7.27 (m, 2H), 7.22 (m, 1H), 5.39 (m, 1H), 4.40 (m, 2H), 3.83 (m, 4H), 3.51 (m, 2H), 3.12 (m, 2H), 2.20 (m, 2H), 1.84 (m, 2H).

Workup

  1. customto react

Sources & evidence

ORD record
ord-5dcae271a5a543fc9827606e7aec1706
Source dataset
uspto-grants-2005_07
Patent number
US06921821B2

Reaction notes

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