2,3-Dihydrobenzofuran-5-carboxaldehyde → HCID 11531660, compound

HRID 897243Notes

Reaction equation

HRID 897243 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][C:7](=[O:12])[CH:6]=[C:5]2[NH:13][CH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.[O:20]1[C:24]2[CH:25]=[CH:26][C:27]([CH:29]=O)=[CH:28][C:23]=2[CH2:22][CH2:21]1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][C:7](=[O:12])[CH:6]=[C:5]2[NH:13][CH:14]1[CH2:19][CH2:18][N:17]([CH2:29][C:27]2[CH:26]=[CH:25][C:24]3[O:20][CH2:21][CH2:22][C:23]=3[CH:28]=2)[CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 7359012,3-Dihydrobenzofuran-5-carboxaldehydeHCID 116376956-Chloro-4-(piperidin-4-ylamino)chromen-2-one

Product 1

HCID 11531660HCID 11531660, compound

Procedure

Prepared from 6-Chloro-4-(piperidin-4-ylamino)-chromen-2-one and 2,3-dihydro-benzofuran-5-carbaldehyde in a manner analogous to that described above. 1H NMR (500 MHz, MeOD-d4) δ ppm 8.13 (s, 1H), 7.61 (d, 1H), 7.33-7.36 (m, 2H), 7.84 (d, 1H), 7.24 (s, 1H), 5.45 (s, 1H), 4.61 (t, 2H), 4.26 (s, 2H), 3.85 (br t, 1H), 3.58 (br d, 2H), 3.26 (t, 2H), 3.16(br t, 2H), 3.35 (br d, 2H), 1.93 (m, 2H).

Sources & evidence

ORD record
ord-234ae6380f7a444e87411df6287a425f
Source dataset
uspto-grants-2005_07
Patent number
US06921821B2

Reaction notes

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