3,4-Dimethylbenzaldehyde → HCID 20817836, compound

HRID 897244Notes

Reaction equation

HRID 897244 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][C:7](=[O:12])[CH:6]=[C:5]2[NH:13][CH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.[CH3:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][C:28]=1[CH3:29])[CH:24]=O>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][C:7](=[O:12])[CH:6]=[C:5]2[NH:13][CH:14]1[CH2:19][CH2:18][N:17]([CH2:24][C:23]2[CH:26]=[CH:27][C:28]([CH3:29])=[C:21]([CH3:20])[CH:22]=2)[CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 222783,4-DimethylbenzaldehydeHCID 116376956-Chloro-4-(piperidin-4-ylamino)chromen-2-one

Product 1

HCID 20817836HCID 20817836, compound

Procedure

Prepared from 6-Chloro-4-(piperidin-4-ylamino)-chromen-2-one and 3,4-dimethyl benzaldehyde in a manner analogous to that described above. MS (ESI) m/e 397.1 (M+H)+. 1H NMR (500 MHz, MeOD-d4) δ ppm 8.12 (d, 1H), 7.60 (dd, 1H), 7.21-7.34 (m, 4H), 5.44 (s, 1H), 4.27 (s, 2H), 3.83-3.87 (m, 1H), 3.55-3.60 (m, 2H), 3.16-3.20 (m, 2H), 2.30-2.38 (m, 2H), 2.33 (s, 3H), 2.31 (s, 3H), 1.89-1.96 (m, 2H).

Sources & evidence

ORD record
ord-fa37bf473ba44ca9bf14d8aae9a9b35f
Source dataset
uspto-grants-2005_07
Patent number
US06921821B2

Reaction notes

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