Ethanol → HCID 22348058, compound

Participants

Reaction Steps

Iron powder (0.067 g, 1.2 mmol) was added to a suspension of ammonium chloride (0.006 g, 0.12 mmol) and 4-(1-Benzo[1.3]dioxol-5-ylmethyl-piperidin-4-ylamino)-6-chloro-3-nitro-chromen-2-one (0.055 g, 0.12 mmol) in ethanol (5 mL) and water (2 mL) at room temperature. The reaction was heated at reflux for 1 d and then filtered through a pad of wet celite. The filtrate was treated with saturated NaHCO3 (10 mL), extracted with dichloromethane (3×25 mL), dried (Na2SO4), concentrated, purified by RP-HPLC and the amine carried forward to the next step. MS (ESI) m/e 428.0 (M+H)+.

Provenance & Evidence