2,3-Dihydro-1,4-benzodioxin-6-carbaldehyde → HCID 22348029, compound

HRID 897250Notes

Reaction equation

HRID 897250 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([NH:7][C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([CH:18]=[CH2:19])[CH:16]=3)[O:11][C:10](=[O:20])[CH:9]=2)[CH2:3][CH2:2]1.[O:21]1[C:26]2[CH:27]=[CH:28][C:29]([CH:31]=O)=[CH:30][C:25]=2[O:24][CH2:23][CH2:22]1>>[O:21]1[C:26]2[CH:27]=[CH:28][C:29]([CH2:31][N:1]3[CH2:6][CH2:5][CH:4]([NH:7][C:8]4[C:17]5[C:12](=[CH:13][CH:14]=[C:15]([CH:18]=[CH2:19])[CH:16]=5)[O:11][C:10](=[O:20])[CH:9]=4)[CH2:3][CH2:2]3)=[CH:30][C:25]=2[O:24][CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 2481272,3-Dihydro-1,4-benzodioxin-6-carbaldehydeHCID 22348214HCID 22348214, compound

Product 1

HCID 22348029HCID 22348029, compound

Procedure

4-(Piperidin-4-ylamino)-6-vinyl-chromen-2-one and 2,3-dihydro-benzo{1,4}dioxine-6-carbaldehyde were allowed to react in a manner analogous to that previously described to give the title compound. 1H NMR (500 MHz, DMSO-D6) δ ppm 1.64 (m, 2H) 1.92 (m, 2H) 2.08 (m, 2H) 2.83 (m, 2H) 3.38 (s, 2H) 3.49 (m, 1H) 4.22 (m, 4H) 5.23 (s, 1H) 5.34 (m, 1H) 5.95 (m, 1H) 6.77 (m, 4H) 7.25 (m, 2H) 7.69 (m, 1H) 8.21 (m, 1H); MS (DCI/NH3) m/z 418 [M+H]+.

Workup

  1. customto react in a manner analogous to

Sources & evidence

ORD record
ord-a35b08523b04403788818015c34b7990
Source dataset
uspto-grants-2005_07
Patent number
US06921821B2

Reaction notes

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