Diisopropylethylamine → HCID 68897131, compound

Participants

Reaction Steps

A solution of isopropyl 3-(chlorocarbonyl)pyridine-2-carboxylate (prepared as in P. Ornstein et. al. J. Med. Chem. 1989, 32, 827) (6.577 g, 31.44 mmol) in CH2Cl2 (50 ml) was added dropwise to a solution of glycine methyl ester hydrochloride (4.34 g, 34.58 mmol) and diisopropylethylamine (12.6 ml, 72.31 mmol) in CH2Cl2 (65 ml) at 0 C. The reaction was stirred for 16 hrs during which time the ice bath was allowed to expire. The solvent was evaporated in vacuo and the residue was used in the next step without further purification.

Provenance & Evidence