HCID 10271271, compound → HCID 10159819, compound

Participants

Reaction Steps

A solution of the chloride from Example 44 Step 5 (40 mg, 0.105 mmol) in piperidine (0.5 ml) was heated at 100 C. for 36 hrs under argon. The resulting solution was cooled to room temperature and the solvent evaporated in vacuo. The residue was dissolved in hot DMF (0.7 ml) and purified by preparative HPLC. (Gilson semi preparative HPLC system and a YMC Combiprep Pro Column (50×20 mm I.D., C18, S-5 um, 120A) eluting with 5-95% acetonitrile/water (0.1% TFA) at 15 ml/min) to afford the title compound after lyophilization.

Provenance & Evidence