Imidazole → HCID 22346333, compound

Participants

Reaction Steps

The chloride from Example 44 Step 5 (8.0 mg, 0.021 mmol) and imidazole (80 mg) were fused at 160 C for 1 hr under argon. The residue was dissolved in DMF (0.5 ml) and purified by preparative HPLC. (Gilson semi preparative HPLC system and a YMC Combiprep Pro Column (50×20 mm I.D., C18, S-5 um, 120A) eluting with 5-95% acetonitrile/water (0.1% TFA) at 15 ml/min) to afford the title compound after lyophilization.

Provenance & Evidence