N-bromobutanimide → Methyl 5-bromo-8-hydroxy-1,6-naphthyridine-7-carboxylate

Participants

Reaction Steps

To a solution of methyl 8-hydroxy-1,6-naphthyridine-7-carboxylate from Example 1 Step 2 (5.0 g, 24.49 mmol) in CH2Cl2 (100 ml) at room temperature was added N-bromo succinimide (4.36 g, 24.49 mmol). The reaction was stirred for 1 hr. The solids were collected by filtration and dried in vacuo to afford the title compound as an off white solid.

Provenance & Evidence