反应详情

To a 25 mL round bottomed flask with a stirring bar, reflux condenser and a nitrogen inlet was added 5-bromo-8-hydroxy-[1,6]naphthyridine-7-carboxylic acid methyl ester (0.511 g, 1.81 mmol) dry toluene (12.5 mL) and 2-methylthiobenzylamine (0.346 g, 2.26 mmol). This mixture was heated at reflux for 24 h. The mixture was cooled to ambient temperature and the toluene was removed in vacuo. The residue was triturated with a little Et2O/hexane, collected on a frit and dried in vacuo to give 8-hydroxy-5-bromo-[1,6]naphthyridine-7-carboxylic acid 2-methylsulfanylbenzylamide as a crystalline solid.

1. temperatureTo a 25 mL round bottomed flask with a stirring bar, reflux condenser and a nitrogen inlet
2. temperatureThis mixture was heated
3. temperatureat reflux for 24 h
4. customthe toluene was removed in vacuo
5. customThe residue was triturated with a little Et2O/hexane
6. customcollected on a frit
7. customdried in vacuo