反应详情

Into a round bottom flask fitted with a gas inlet, condenser and a magnetic stirring bar was placed methyl 8-(benzoyloxy)-5-bromo-1,6-naphthyridine-7-carboxylate (0.4 g, 1.03 mmol), 2,3-dimethoxybenzylamine (0.432 g, 0.38 mL, 2.58 mmol) and 10 mL toluene. This mixture was refluxed for 18 hours, after which the reaction was cooled and the solvent removed in vacuo. The resulting residue was triturated with diethyl ether and filtered to yield 5-bromo-N-(2,3-dimethoxybenzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamide as a light yellow solid.

1. customInto a round bottom flask fitted with a gas inlet, condenser and a magnetic stirring bar
2. temperatureThis mixture was refluxed for 18 hours
3. temperatureafter which the reaction was cooled
4. customthe solvent removed in vacuo
5. customThe resulting residue was triturated with diethyl ether
6. filtrationfiltered