反应详情

To a solution of 5-hydroxy-2-methyl pyridine (20 g, 183.2 mmol) in dry pyridine (350 mL) was added a solution of bromine (10.3 mL, 201.5 mmol) in dry pyridine (100 mL) dropwise. After 1.5 h, the reaction mixture was filtered and the filtrate was concentrated under vacuum. The residue was treated with water (160 mL) and filtered. The resultant pale solid was washed with water (300 mL) and air dried. The crude product was recrystallized in EtOH (200 mL) to give the title compound as a solid.

1. filtrationthe reaction mixture was filtered
2. concentrationthe filtrate was concentrated under vacuum
3. additionThe residue was treated with water (160 mL)
4. filtrationfiltered
5. washThe resultant pale solid was washed with water (300 mL) and air
6. customdried
7. customThe crude product was recrystallized in EtOH (200 mL)