HCID 20816871, compound → HCID 22346320, compound

HRID 897311Notes

Reaction equation

HRID 897311 reaction equation
[F:1][C:2]1[CH:28]=[CH:27][C:5]([CH2:6][NH:7][C:8]([C:10]2[C:19]([OH:20])=[C:18]3[C:13]([CH:14]=[CH:15][CH:16]=[N:17]3)=[C:12](/[CH:21]=[CH:22]/[C:23]([O:25]C)=O)[N:11]=2)=[O:9])=[CH:4][CH:3]=1.FC1C=CC([CH2:34][NH:35][C:36](C2C(O)=C3C(C=CC=N3)=C(CCC(OC)=O)N=2)=O)=CC=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][NH:7][C:8]([C:10]2[C:19]([OH:20])=[C:18]3[C:13]([CH:14]=[CH:15][CH:16]=[N:17]3)=[C:12](/[CH:21]=[CH:22]/[C:23]([N:35]([CH3:36])[CH3:34])=[O:25])[N:11]=2)=[O:9])=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 20816871HCID 20816871, compoundHCID 22346415HCID 22346415, compound

Product 1

HCID 22346320HCID 22346320, compound

Procedure

The title compound was prepared using a procedure similar to that described in Example 147, Step 2, except that methyl (2E)-3-(7-{[(4-fluorobenzyl)amino]carbonyl}-8-hydroxy[1,6]-naphthyridin-5-yl)-2-propenoate (Example 137, Step 1) was substituted for methyl 3-(7-{[(4-fluorobenzyl)amino]carbonyl}-8-hydroxy[1,6]-naphthyridin-5-yl)propanoate.

Sources & evidence

ORD record
ord-458b9efa00444a6099d4b95ce52ef18d
Source dataset
uspto-grants-2005_07
Patent number
US06921759B2

Reaction notes

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