Ethanol → HCID 68896800, compound

HRID 897370Notes

Reaction equation

HRID 897370 reaction equation
[O:1]=[S:2]1(=[O:33])[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[C:8]1[N:17]=[C:16]([C:18]([NH:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[S:28]([CH3:31])(=[O:30])=[O:29])=[O:19])[C:15]([OH:32])=[C:14]2[C:9]=1[CH:10]=[CH:11][CH:12]=[N:13]2.C(O)C.[OH-].[Na+:38]>CC(C)=O>[O:33]=[S:2]1(=[O:1])[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[C:8]1[N:17]=[C:16]([C:18]([NH:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[S:28]([CH3:31])(=[O:30])=[O:29])=[O:19])[C:15]([O-:32])=[C:14]2[C:9]=1[CH:10]=[CH:11][CH:12]=[N:13]2.[Na+:38]

Participants

5

Reactant 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 20816860HCID 20816860, compound

Product 1

HCID 68896800HCID 68896800, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

5-(1,1-dioxido-1,2-thiazinan-2-yl)-8-hydroxy-N-[2-(methylsulfonyl)benzyl]-1,6-naphthyridine-7-carboxamide (53 mg, 0.108 mmol) was suspended in a 1:1 mixture of ethanol and acetone (1 mL each). NaOH (130 uL, 1 M) was added and the starting material dissolved. After 1 hour the sodium salt precipitated. The sample was concentrated in vacuo to afford the desired material as a yellow solid.

Workup

  1. dissolutionthe starting material dissolved
  2. customAfter 1 hour the sodium salt precipitated
  3. concentrationThe sample was concentrated in vacuo

Sources & evidence

ORD record
ord-ba3ce39d8c3c495f988437b993b6fd8e
Source dataset
uspto-grants-2005_07
Patent number
US06921759B2

Reaction notes

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