4-tributylstannyl-5H-furan-2-one → HCID 22346469, compound

Participants

Reaction Steps

The iodide from step 2 (4.37 g, 10.32 mmol) was dissolved in anhydrous toluene (40 ml) in an oven dried flask that was purged with nitrogen. Dichlorobis(triphenylphospine)palladium (II) (660 mgs., 0.94 mmol) and 4-(tributylstannyl)furan-2(5H)-one, (3.85 g, 10.32 mmol) (prepared as described by Gregory J. Hollingworth, Gemma Perkins, and Joseph Sweeney, J. Chem. Soc., Perkins 1. 1996, 1913) were then added to the reaction. After four hours at reflux the reaction was cooled and the solids that precipitated from the solution were collected by vacuum filtration. The product contained 17% of an impurity: N,N′-bis(4-fluorobenzyl)-8,8′-dihydroxy-5,5′-bi-1,6-naphthyridine-7,7′-dicarboxamide.

Provenance & Evidence