Ammonia → HCID 54300456, compound

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Reaction Steps

A solution of methyl (2S,3R)-3-amino-2-methyl-3-phenylpropionate (6.3 g, 33 mmol) in 2N methanolic ammonia (20 ml) and ammonium hydroxide (28-30%, 40 ml) was stirred at room temperature. After 4 d, concentration followed by chromatography on a short column of silica gel (dichloromethane-methanol-conc. ammonium hydroxide=93:7:0.7; 90:10:0.8) provided the amide as a white solid. MS (m/z): 179.2 (M+H)+; C10H14N2O requir. 178.2.

Provenance & Evidence