HCID 10023113, compound → HCID 57205166, compound

HRID 897389Notes

Reaction equation

HRID 897389 reaction equation
[CH3:1][C@H:2]([CH2:11][NH2:12])[C@H:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[NH2:4].C(N([C@H](C1C=CC=CC=1)[C@@H](C)C(OC)=O)[C@H](C)C1C=CC=CC=1)C1C=CC=CC=1>>[CH3:1][C@@H:2]([CH2:11][NH2:12])[C@@H:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[NH2:4]

Participants

3

Reactant 2

HCID 10023113HCID 10023113, compoundHCID 21355906HCID 21355906, compound

Product 1

HCID 57205166HCID 57205166, compound

Procedure

The title compound was prepared as described in the example for the synthesis of the enantiomer, (1R,2R)-2-methyl-1-phenyl-1,3-propanediamine, from methyl (2R,3S,αR)-3-(N-benzyl-N-α-methylbenzylamino)-2-methyl-3-phenylpropionate (Davies et al., J. Chem. Soc. Chem. Commun. 1153-1155, 1993). The title compound was obtained as a crystallizing oil, MS (m/z): 165.3 (M+H)+; C10H16N2 requir. 164.3.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-31c77135d15042368464147f21ecfb33
Source dataset
uspto-grants-2005_07
Patent number
US06921762B2

Reaction notes

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