Phosphorus oxychloride → 2-Chloro-3-methyl-6-pyridin-4-yl-5-m-tolyl-3H-pyrimidin-4-one

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Reaction Steps

A mixture of 3-methyl-5-(3-methylphenyl)-6-(4-pyridyl)-(1H,3H)-pyrimidin-2,4-dione (12.5 g, 0.043 mol) and phosphorus oxychloride (65 ml) was refluxed for 16 h. The excess of phosphorus oxychloride was evaporated followed by co-distillation with toluene. The remainder was carefully partitioned between dichloromethane and aqueous sodium hydrogencarbonate. The organic solution was washed with water, dried and evaporated to leave the title compound; MS (m/z): 312 (M+H)+; C17H14ClN3O requir. 311.8.

Provenance & Evidence