Hydrazine hydrate (1:1) → HCID 22346624, compound

Participants

Reaction Conditions

Reaction Steps

2-((1-methyl-1-phenylethyl)amino)-4-chloro-5-(4-fluorophenyl)-6-(4-pyridyl)pyrimidine (218 mg, 0.52 mmol) was combined with a solution of hydrazine hydrate (130 mg 2.60 mmol) and isopropylalcohol (ca. 10 mL). The mixture was heated at 70° C. for 4 h. The reaction was cooled to RT, the solvent was evaporated in vacuo and the residue was purified by flash chromatography (2% MeOH:CHCl3) to provide the product as an off-white solid; MS m/z (M+H)+ 415; C24H23FN6 requir. 414.5.

Provenance & Evidence