HCID 11371703, compound → HCID 12037374, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-methyl-4-oxo-6-(4-pyridyl)-5-(3-(trifluoromethyl)-phenyl)-3H-pyrimidine-2-carbonitrile (280 mg, 0.79 mmole) in THF (20 mL) was added phenethylene magnesium chloride (1.0M in THF, 1.2 mL) at 0° C. The reaction solution was then stirred at 0° C. for 5 mins. The mixture was partitioned between sat. ammonium chloride and ethyl acetate. The organic layer was separated, dried over sodium sulfate, filtered and concentrated to a syrup. The residue was purified by column chromatography on silica gel (30% ethyl acetate in hexane) to give the product as a syrup; MS (m/z) 436(M+H)+; C25H20F3N3O requir. 435.4.

Provenance & Evidence