5-(1-(t-butoxycarbonyl)-1,2,3,6-tetrahydropyrid-4-yl)-7-(2-(1(S)-phenylethyl)amino-4-pyridyl)-8-(3-(trifluoromethyl)phenyl)-1,2,4-triazolo[4,3-c]pyrimidine → 5-(2(R)-(hydroxymethyl)pyrrolidin-1-yl)-7-(2-(1(S)-phenylethyl)amino-4-pyridyl)-8-(3-(trifluoromethyl)phenyl)-1,2,4-triazolo[4,3-c]pyrimidine

Participants

Role	Name	HCID	Charge
Reactant	5-(1-(t-butoxycarbonyl)-1,2,3,6-tetrahydropyrid-4-yl)-7-(2-(1(S)-phenylethyl)amino-4-pyridyl)-8-(3-(trifluoromethyl)phenyl)-1,2,4-triazolo[4,3-c]pyrimidine	HCID 20816904	—
Reactant	5-(2(R)-(hydroxymethyl)-pyrrolidin-1-yl)-7-(2-chloro-4-pyridyl)-8-(3-(trifluoromethyl)phenyl)-1,2,4-triazolo[4,3-c]pyrimidine	HCID 20816908	—
Product	5-(2(R)-(hydroxymethyl)pyrrolidin-1-yl)-7-(2-(1(S)-phenylethyl)amino-4-pyridyl)-8-(3-(trifluoromethyl)phenyl)-1,2,4-triazolo[4,3-c]pyrimidine	HCID 20816907	—

Reaction Steps

The title compound was synthesized from 5-(2(R)-(hydroxymethyl)-pyrrolidin-1-yl)-7-(2-chloro-4-pyridyl)-8-(3-(trifluoromethyl)phenyl)-1,2,4-triazolo[4,3-c]pyrimidine in the same manner as 5-(1-(t-butoxycarbonyl)-1,2,3,6-tetrahydropyrid-4-yl)-7-(2-(1(S)-phenylethyl)amino-4-pyridyl)-8-(3-(trifluoromethyl)phenyl)-1,2,4-triazolo[4,3-c]pyrimidine; MS (m/z) 560.4 (M+H)+; C30H28F3N7O requir. 559.59.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06921762B2
Source dataset	uspto-grants-2005_07
ORD ID	ord-52f4b5b971b04086b8faf3758bdb199a
Source note	uspto-grants-2005_07