Maleic Acid → 1-[1-(4-piperidyl)-4-piperidyl]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, trimaleate salt

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Reaction Steps

1-[1-(4-piperidyl)-4-piperidyl]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (108 mg, 0.230 mmol) was dissolved in 25 ml of ethanol and maleic acid (80 mg, 0.690 mmol) in 5 ml of hot ethanol was added. After 2 hours at room temperature, the solid was filtered and dried to give 155 mg of 1-[1-(4-piperidyl)-4-piperidyl]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, trimaleate salt. 1H NMR (DMSO) 1.80(m, 2H), 2.42(m, 4), 2.51(m, 2H), 2.95(m, 3H), 3.44(bm, 7H), 5.06(m, 1H), 6.10 (s, 6H), 7.15(m, 5H), 7.45(m, 2H), 7.67(d, J=8.51 Hz, 2H), 8.27(s, 1H); LC/MS (MH+=484).

Provenance & Evidence