beta-Phenylisovaleric acid → 3-Methyl-3-phenylbutanoyl chloride

Participants

Reaction Conditions

Reaction Steps

A solution of 3-methyl-3-phenylbutyric acid (0.508 g, 2.85 mmol) in dichloromethane (10 μL) at −78° C. was treated with oxalyl chloride (3.62 , 28.5 mmol) and 1 drop of dimethylformamide. The reaction mixture was stirred at −78° C. for 10 min, and dry ice/acetone bath was removed to stir at room temperature over night. Solvent was removed under reduced pressure, and dried under high vacuum. The product was used directly for subsequent reaction without analysis.

Provenance & Evidence