HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-Methoxy-N-methylcyclopropanecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Cyclopropanecarbonyl chloride | HCID 77637 | — |
| Reactant | Methanamine, N-methoxy-, hydrochloride (1:1) | HCID 81138 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-Methoxy-N-methylcyclopropanecarboxamide | HCID 15643267 | 61.4% |
Reaction Steps
N,O-dimethyl-hydroxylamine HCl (40 g, 410 mmol) was suspended under nitrogen in DCM (400 mL) and cooled in ice. Triethylamine (63 mL, 451 mmol) was added slowly, then cyclopropanecarbonyl chloride (41 mL, 451 mmol) was added slowly. Stirring without cooling was continued for 1 h. Extraction: 2×DCM, 1×1 N HCl, 1×NaCl. Distillation: 75° C./20 mbar. One obtained 32.5 g (61%) of a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07351700B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-7c669845a24a43bb8a9dda151da4a71a |
| Source note | uspto-grants-2008_04 |