HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 4-(2-Hexylsulfanyl-6-methyl-pyrimidin-4-ylmethyl)-morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (Hexylsulfanyl)methanimidamide hydrobromide | HCID 12387367 | — |
| Reactant | 5-(Morpholin-4-yl)pent-3-yn-2-one | HCID 67467749 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(2-Hexylsulfanyl-6-methyl-pyrimidin-4-ylmethyl)-morpholine | HCID 11449731 | — |
Reaction Steps
5-Morpholin-4-yl-pent-3-yn-2-one (1 g, 6 mmol) and 2-hexyl-isothiourea hydrobromide (1.06 g, 7 mmol) were dissolved under nitrogen in DMF (10 mL), then N,N-diisopropyl ethylamine (4.1 mL, 24 mmol) was added and stirring at the room temperature continued for 18 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07351700B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-41d0e0c52dd248a5b010bd4b8401643a |
| Source note | uspto-grants-2008_04 |