HCID 68568205, compound → HCID 23627719, compound

HRID 898147Notes

Reaction equation

HRID 898147 reaction equation
N1([C:7]2[N:12]=[C:11]3NC=C[C:10]3=[CH:9][CH:8]=2)CCNCC1.Cl.[CH:17]1([N:22]2[CH2:27][CH2:26][N:25]([C:28]3[N:33]=[C:32]4[NH:34][C:35]([C:37](O)=[O:38])=[CH:36][C:31]4=[CH:30][CH:29]=3)[CH2:24][CH2:23]2)[CH2:21][CH2:20][CH2:19][CH2:18]1>>[CH:17]1([N:22]2[CH2:23][CH2:24][N:25]([C:28]3[N:33]=[C:32]4[NH:34][C:35]([C:37]([N:12]5[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]5)=[O:38])=[CH:36][C:31]4=[CH:30][CH:29]=3)[CH2:26][CH2:27]2)[CH2:18][CH2:19][CH2:20][CH2:21]1

Participants

3

Reactant 2

HCID 68568205HCID 68568205, compoundHCID 68568912HCID 68568912, compound

Product 1

HCID 23627719HCID 23627719, compound

Procedure

According to the procedure described for the synthesis of Example 1 further 6-piperazinyl-1H-pyrrolo[2,3-b]pyridine derivatives have been synthesized from 6-(4-cyclopentyl-piperazin-1-yl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid hydrochloride (as prepared in step 2) and the respective amine mentioned in table 1. The examples are compiled in table 1 and comprise Example 2 to Example 20.

Sources & evidence

ORD record
ord-b633c4419f78422cb2be191ef0f428e5
Source dataset
uspto-grants-2008_04
Patent number
US07351708B2

Reaction notes

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