HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 898157Generated: October 26, 2026
Water → 3-(4-Bromobenzyl)-8-(3,3-diphenyl-propyl)-1,3,8-triaza-spiro[4.5]decane-2,4-dione Hydrochloride
https://huagongshe.com/reaction/898157
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1,1'-(3-Bromopropylidene)bisbenzene | HCID 88333 | — |
| Reactant | 3-(4-Bromo-benzyl)-1,3,8-triaza-spiro[4.5]decane-2,4-dione hydrochloride | HCID 69207577 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-(4-Bromobenzyl)-8-(3,3-diphenyl-propyl)-1,3,8-triaza-spiro[4.5]decane-2,4-dione Hydrochloride | HCID 69207606 | 32.1% |
Reaction Steps
A mixture of 26.2 mg (70 μmol) of 3-(4-bromo-benzyl)-1,3,8-triaza-spiro[4.5]decane-2,4-dione hydrochloride, 21.4 mg (70 μmol) of 3,3-diphenylpropyl bromide and 29 mg (210 μmol) of potassium carbonate in 1 mL of anhydrous DMF was heated overnight at 60° C. After cooling to room temperature, 0.5 mL of water was added and the solution was extracted with DCM (2×2 mL). The crude material was purified by semi-preparative HPLC (method A) yielding 12.8 mg (32.1%) of Compound 3 as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07351713B2 |
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| Source dataset | uspto-grants-2008_04 |
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| ORD ID | ord-a6288280573245c68b10df567eb51a5b |
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| Source note | uspto-grants-2008_04 |
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