m-Anisoyl chloride → (3R)-3-ethyl-7-fluoro-4-(3-methoxybenzoyl)-3,4-dihydroquinoxalin-2(1H)-one

Participants

Reaction Steps

(3R)-3-Ethyl-7-fluoro-3,4-dihydroquinoxalin-2(1H)-one (see Example 1) was treated with 3-methoxybenzoyl chloride according to the procedure for the preparation of (3R)-3-ethyl-7-fluoro-4-(4-methoxybenzoyl)-3,4-dihydroquinoxalin-2(1H)-one (see Example 1) to yield (3R)-3-ethyl-7-fluoro-4-(3-methoxybenzoyl)-3,4-dihydroquinoxalin-2(1H)-one (76%). MS (ESI) m/z 329 ([M+H]+); MS (ESI) m/z 327 ([M−H]−); HRMS: calcd for C18H17FN2O3, 328.12238; found (ESI+), 329.12924.

Provenance & Evidence