HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3S)-3-Ethyl-6-fluoro-3,4-dihydroquinoxalin-2(1H)-one → (3S)-3-ethyl-6-fluoro-4-(4-methoxybenzoyl)-3,4-dihydroquinoxalin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3S)-3-Ethyl-6-fluoro-3,4-dihydroquinoxalin-2(1H)-one | HCID 49857655 | — |
| Reactant | (3R)-3-ethyl-7-fluoro-4-(4-methoxybenzoyl)-3,4-dihydroquinoxalin-2(1H)-one | HCID 69224280 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | (3S)-3-ethyl-6-fluoro-4-(4-methoxybenzoyl)-3,4-dihydroquinoxalin-2(1H)-one | HCID 69223582 | 82% |
Reaction Steps
(3S)-3-Ethyl-6-fluoro-3,4-dihydroquinoxalin-2(1H)-one in ether was treated according to the procedure for the preparation of (3R)-3-ethyl-7-fluoro-4-(4-methoxybenzoyl)-3,4-dihydroquinoxalin-2(1H)-one (see Example 1) to yield (3S)-3-ethyl-6-fluoro-4-(4-methoxybenzoyl)-3,4-dihydroquinoxalin-2(1H)-one (82%). MS (ESI) m/z 329 ([M+H]+); MS (ESI) m/z 327 ([M−H]−).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07351709B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-5fec4b9753a74f2289db9cbbb321d2e8 |
| Source note | uspto-grants-2008_04 |