HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3R)-3-Ethyl-7-fluoro-3,4-dihydroquinoxalin-2(1H)-one → (3R)-3-ethyl-6-fluoro-3,4-dihydroquinoxalin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3R)-3-Ethyl-7-fluoro-3,4-dihydroquinoxalin-2(1H)-one | HCID 69220784 | — |
| Reactant | (R)-2-(5-fluoro-2-nitrophenylamino)-butyric acid | HCID 69221394 | — |
| Product | (3R)-3-ethyl-6-fluoro-3,4-dihydroquinoxalin-2(1H)-one | HCID 69222176 | 54% |
Reaction Steps
(2R)-2-(5-Fluoro-2-nitrophenylamino)-butyric acid was treated according to the procedure for the preparation of (3R)-3-ethyl-7-fluoro-3,4-dihydroquinoxalin-2(1H)-one (see Example 1) to yield (3R)-3-ethyl-6-fluoro-3,4-dihydroquinoxalin-2(1H)-one (54%). MS (ESI) m/z 195 ([M+H]+); HRMS: calcd for C10H11FN2O, 194.08558; found (ESI_FT), 195.08807; Anal. Calcd for C10H11FN2O: C, 61.85; H, 5.71; N, 14.42. Found: C, 61.77; H, 5.76; N, 14.33.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07351709B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-199eb6c28bf1473ca3721f728faedd35 |
| Source note | uspto-grants-2008_04 |