HRID898235

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC[C@@H]1C(=O)N(C)c2cc(F)ccc2N1C(=O)c1ccc(O)cc1

HCID11709655

未命名化合物

结构：CC[C@@H]1C(=O)N(C(C)C)c2ccc(F)cc2N1C(=O)c1ccc(OC)cc1

HCID69221297

未命名化合物

PRODUCTS

生成物

结构：CC[C@@H]1C(=O)N(C(C)C)c2ccc(F)cc2N1C(=O)c1ccc(O)cc1

HCID11610093

未命名化合物

收率 92%

PROCEDURE

实验过程

(3R)-3-Ethyl-6-fluoro-4-(4-methoxybenzoyl)-1-isopropyl-3,4-dihydroquinoxalin-2(1H)-one was treated according to the procedure for the preparation of (3R)-3-ethyl-7-fluoro-4-(4-hydroxybenzoyl)-1-methyl-3,4-dihydroquinoxalin-2(1H)-one (see Example 1) to yield (3R)-3-ethyl-6-fluoro-4-(4-hydroxybenzoyl)-1-isopropyl-3,4-dihydroquinoxalin-2(1H)-one (92%). [α]D25=−309° (c=0.0099 G/ML, CHCl3); MS (ESI) m/z 357 ([M+H]+); MS (ESI) m/z 355 ([M−H]−); HRMS: calcd for C20H21FN2O3, 356.1536; found (ESI_FT), 357.16064.