HRID898237

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC[C@@H]1C(=O)N(C)c2cc(F)ccc2N1C(=O)c1ccc(O)cc1

HCID11709655

未命名化合物

结构：CCCCN1C(=O)[C@@H](CC)N(C(=O)c2ccc(OC)cc2)c2cc(F)ccc21

HCID69221484

未命名化合物

PRODUCTS

生成物

结构：CCCCN1C(=O)[C@@H](CC)N(C(=O)c2ccc(O)cc2)c2cc(F)ccc21

HCID11696372

未命名化合物

收率 94%

PROCEDURE

实验过程

(3R)-1-Butyl-3-ethyl-6-fluoro-4-(4-methoxybenzoyl)-3,4-dihydroquinoxalin-2(1H)-one was treated according to the procedure for the preparation of (3R)-3-ethyl-7-fluoro-4-(4-hydroxybenzoyl)-1-methyl-3,4-dihydroquinoxalin-2(1H)-one (see Example 1) to yield (3R)-1-butyl-3-ethyl-6-fluoro-4-(4-hydroxybenzoyl)-3,4-dihydroquinoxalin-2(1H)-one (94%). [α]D25=−268° (c=0.0103G/ML, CHCl3); MS (ESI) m/z 371 ([M+H]+); MS (ESI) m/z 369 ([M−H]−); HRMS: calcd for C21H23FN2O3, 370.1693; found (ESI_FT), 371.17594; Anal. Calcd for C21H23FN2O3: C, 68.09; H, 6.26; N, 7.56. Found: C, 67.96; H, 6.60; N, 7.67.