(3R)-3-ethyl-7-fluoro-4-(4-hydroxybenzoyl)-1-methyl-3,4-dihydroquinoxalin-2(1H)-one → (3R)-3-ethyl-6-fluoro-4-(4-hydroxybenzoyl)-1-pentyl-3,4-dihydroquinoxalin-2(1H)-one

Participants

Reaction Steps

(3R)-3-Ethyl-6-fluoro-4-(4-methoxybenzoyl)-1-pentyl-3,4-dihydroquinoxalin-2(1H)-one was treated according to the procedure for the preparation of (3R)-3-ethyl-7-fluoro-4-(4-hydroxybenzoyl)-1-methyl-3,4-dihydroquinoxalin-2(1H)-one (see Example 1) to yield (3R)-3-ethyl-6-fluoro-4-(4-hydroxybenzoyl)-1-pentyl-3,4-dihydroquinoxalin-2(1H)-one (96%). [α]D 25=−294° (c=0.0095 G/ML, CHCl3); MS (ESI) m/z 385 ([M+H]+); MS (ESI) m/z 383 ([M−H]−); HRMS: calcd for C22H25FN2O3.0.10H2O, 385.9860; found (ESI_FT), 385.19204.

Provenance & Evidence