(3R)-3-ethyl-7-fluoro-4-(4-hydroxybenzoyl)-1-methyl-3,4-dihydroquinoxalin-2(1H)-one → (3R)-3-ethyl-6-fluoro-4-(4-hydroxybenzoyl)-1-(2,2,2-trifluoroethyl)-3,4-dihydroquinoxalin-2(1H)-one

Participants

Reaction Steps

(3R)-3-Ethyl-6-fluoro-4-(4-methoxybenzoyl)-1-(2,2,2-trifluoroethyl)-3,4-dihydroquinoxalin-2(1H)-one was treated according to the procedure for the preparation of (3R)-3-ethyl-7-fluoro-4-(4-hydroxybenzoyl)-1-methyl-3,4-dihydroquinoxalin-2(1H)-one (see Example 1) to yield (3R)-3-ethyl-6-fluoro-4-(4-hydroxybenzoyl)-1-(2,2,2-trifluoroethyl)-3,4-dihydroquinoxalin-2(1H)-one (73%). [α]D25=−137° (c=0.010 G/ML, CHCl3); MS (ESI) m/z 397 ([M+H]+); MS (ESI) m/z 395 ([M−H]−); HRMS: calcd for C19H16F4N2O3, 396.1097; found (ESI_FT), 397.11588.

Provenance & Evidence