(3R)-3-Ethyl-7-fluoro-3,4-dihydroquinoxalin-2(1H)-one → (S)-6-Fluoro-3-methyl-3,4-dihydroquinoxalin-2(1H)-one

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Reaction Steps

N-(5-Fluoro-2-nitrophenyl)-L-alanine was treated according to the procedure for the preparation of (3R)-3-ethyl-7-fluoro-3,4-dihydroquinoxalin-2(1H)-one (see Example 1) to yield (3S)-6-fluoro-3-methyl-3,4-dihydroquinoxalin-2(1H)-one. MS (ESI) m/z 181 ([M+H]+); Anal. Calcd for C9H9FN2O: C, 59.99; H, 5.03; N, 15.55. Found: C, 59.89; H, 4.88; N, 15.46.

Provenance & Evidence