Iodoethane → (3S)-1,3-diethyl-6-fluoro-4-[(4-hydroxyphenyl)sulfonyl]-3,4-dihydroquinoxalin-2(1H)-one

Participants

Reaction Steps

4-{[(2S)-2-ethyl-7-fluoro-3-oxo-3,4-dihydroquinoxalin-1 (2H)-yl]sulfonyl}phenyl carbonate (see Example 20) was treated with iodoethane according to the procedure for the preparation of (3S)-3-ethyl-6-fluoro-4-[(4-hydroxyphenyl)sulfonyl]-1-propyl-3,4-dihydroquinoxalin-2(1H)-one (see Example 20) to yield (3S)-1,3-diethyl-6-fluoro-4-[(4-hydroxyphenyl)sulfonyl]-3,4-dihydroquinoxalin-2(1H)-one. [α]D25=−7° (c=0.0077 G/ML, DMSO); MS (ESI) m/z 379 ([M+H]+); MS (ESI) m/z 377 ([M−H]−); HRMS: calcd for C18H19FN2O4S, 378.1050; found (ESI+), 379.11178.

Provenance & Evidence