反应详情

4-{[(2S)-2-ethyl-7-fluoro-3-oxo-3,4-dihydroquinoxalin-1 (2H)-yl]sulfonyl}phenyl carbonate (see Example 20) was treated with iodomethane according to the procedure for the preparation of (3S)-3-ethyl-6-fluoro-4-[(4-hydroxyphenyl)sulfonyl]-1-propyl-3,4-dihydroquinoxalin-2(1H)-one (see Example 20) to yield (3S)-3-ethyl-4-[(4-hydroxyphenyl)sulfonyl]-1,6-dimethyl-3,4-dihydroquinoxalin-2(1H)-one. [α]D25=−123° (c=0.0057 G/ML, DMSO); MS (ESI) m/z 361 ([M+H]+); MS (ESI) m/z 359 ([M−H]−); Anal. Calcd for C18H20N2O4S: C, 59.98; H, 5.59; N, 7.77. Found: C, 57.75; H, 5.20; N, 7.42.