4-Methoxybenzenesulfonyl chloride → (3S)-3-ethyl-7-fluoro-4-[(4-methoxyphenyl)sulfonyl]-3,4-dihydroquinoxalin-2(1H)-one

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Reaction Steps

(3S)-3-Ethyl-7-fluoro-3,4-dihydroquinoxalin-2(1H)-one was treated with 4-methoxybenzenesulfonyl chloride according to the procedure for the preparation of ethyl 4-{[(2S)-2-ethyl-7-fluoro-3-oxo-3,4-dihydroquinoxalin-1 (2H)-yl]sulfonyl}phenyl carbonate (see Example 20) to yield (3S)-3-ethyl-7-fluoro-4-[(4-methoxyphenyl)sulfonyl]-3,4-dihydroquinoxalin-2(1H)-one. [α]D25=−12.1° (c=0.006 G/ML, DMSO); MS (ESI) m/z 365 ([M+H]+); MS (ESI) m/z 363 ([M−H]−); Anal. Calcd for C17H17FN2O4S: C, 56.03; H, 4.70; N, 7.69. Found: C, 55.99; H, 4.57; N, 7.62.

Provenance & Evidence