(3S)-7-bromo-3-ethyl-3,4-dihydroquinoxalin-2(1H)-one → (3S)-6-bromo-3-ethyl-3,4-dihydroquinoxalin-2(1H)-one

HRID 898275Notes

Reaction equation

HRID 898275 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N+:15]([O-])=O)=[C:6]([NH:8][C@@H:9]([CH2:13][CH3:14])[C:10](O)=[O:11])[CH:7]=1.BrC1C=C2C(N[C@@H](CC)C(=O)N2)=CC=1>>[Br:1][C:2]1[CH:7]=[C:6]2[C:5](=[CH:4][CH:3]=1)[NH:15][C:10](=[O:11])[C@H:9]([CH2:13][CH3:14])[NH:8]2

Participants

3

Reactant 2

HCID 69223263(3S)-7-bromo-3-ethyl-3,4-dihydroquinoxalin-2(1H)-oneHCID 69223544(2S)-2-[(5-bromo-2-nitrophenyl)amino]butanoic acid

Product 1

HCID 69220487(3S)-6-bromo-3-ethyl-3,4-dihydroquinoxalin-2(1H)-one

Procedure

(2S)-2-[(5-bromo-2-nitrophenyl)amino]butanoic acid was treated according to the procedure for the preparation of (3S)-7-bromo-3-ethyl-3,4-dihydroquinoxalin-2(1H)-one (see Example 31) to yield (3S)-6-bromo-3-ethyl-3,4-dihydroquinoxalin-2(1H)-one.

Sources & evidence

ORD record
ord-d220fdcb3bd94676ac868a0e1dbddc67
Source dataset
uspto-grants-2008_04
Patent number
US07351709B2

Reaction notes

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